For the same reason also the fatal dose of the living agar culture injected into the peritoneal cavity is smaller than that of the sterilised culture as has been stated above, for in the latter the effect produced is only that of the intracellular poison injected, whereas in the former must be added also the action of the poisons elaborated in the peritoneal fluid by the That there exists a notable difference between the intracellular poison and the toxins elaborated by the bacilli in the culture medium is strikingly shown by the fact that protected guinea-pigs which have survived the intraperitoneal injection of fatal doses of Haffkine's"virus fort," mentioned on f irmer pages, when subsequently inoculated peritoneally with gelatine culture (liquefied by the growth) of the cholera bacilli promptly succumb, thus proving that, though pro tected against the intracellular poison, tlipv are by no means protected against the toxins elaborated in the culture medium condition against the intracellular poison is established it does not follow tliat this refractory condition necessarily holds good also against the specific toxins or against the growth and multiplication of the bacilli and the production by them of their specific toxins in that refractory body:

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